Modulation of Poliovirus Replicative Fitness in HeLa Cells by Deoptimization of Synonymous Codon Usage in the Capsid Region

We replaced degenerate codons for nine amino acids within the capsid region of the Sabin type 2 oral poliovirus vaccine strain with corresponding nonpreferred synonymous codons. Codon replacements were introduced into four contiguous intervals spanning 97% of the capsid region. In the capsid region...

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Bibliographic Details
Main Authors: Burns, Cara Carthel, Shaw, Jing, Campagnoli, Ray, Jorba, Jaume, Vincent, Annelet, Quay, Jacqueline, Kew, Olen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Genetic Diversity and Evolution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440415/
https://ncbi.nlm.nih.gov/pubmed/16537593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3259-3272.2006
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