Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4(+) T Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy

Maraviroc is a CCR5 antagonist used in the treatment of HIV-1 infection. We and others have suggested that maraviroc could reactivate latent HIV-1. To test the latency-reversing potential of maraviroc and the mechanisms involved, we performed a phase II, single-center, open-label study in which mara...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Madrid-Elena, Nadia, García-Bermejo, María Laura, Serrano-Villar, Sergio, Díaz-de Santiago, Alberto, Sastre, Beatriz, Gutiérrez, Carolina, Dronda, Fernando, Coronel Díaz, María, Domínguez, Ester, López-Huertas, María Rosa, Hernández-Novoa, Beatriz, Moreno, Santiago
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899181/
https://ncbi.nlm.nih.gov/pubmed/29444937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01931-17
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