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Biphasic effects of selective serotonin reuptake inhibitors on anxiety: rapid reversal of escitalopram’s anxiogenic effects in the novelty-induced hypophagia (NIH) test in mice?

In humans, chronic treatment with selective serotonin reuptake inhibitors (SSRIs) decreases anxiety, unlike acute treatment, which can increase anxiety. Although this biphasic pattern is observed clinically, preclinical demonstrations are rare. In an animal model of antidepressant-induced anxiolytic...

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Detalhes bibliográficos
Publicado no:Behav Pharmacol
Main Authors: Koek, Wouter, Mitchell, Nathan C., Daws, Lynette C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899064/
https://ncbi.nlm.nih.gov/pubmed/29035921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FBP.0000000000000345
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