Intrahippocampal injection of a lentiviral vector expressing neurogranin enhances cognitive function in 5XFAD mice

Progressive cognitive declines are the main clinical symptoms of Alzheimer’s disease (AD). Cognitive impairment in AD is directly correlated with amyloid beta (Aβ)-mediated synaptic deficits. It is known that upregulation of neurogranin (Ng), a postsynaptic protein, contributes to the enhancement of...

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Vydáno v:Exp Mol Med
Hlavní autoři: Jeon, Seong Gak, Kang, Moonkyung, Kim, Yeon-Soo, Kim, Dong-Hyun, Nam, Dong Woo, Song, Eun Ji, Mook-Jung, Inhee, Moon, Minho
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898899/
https://ncbi.nlm.nih.gov/pubmed/29568074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.302
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