Metabotropic Glutamate Receptor 2/3 (mGluR2/3) Activation Suppresses TRPV1 Sensitization in Mouse, But Not Human, Sensory Neurons

The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research. We recently demonstrated that in mouse and human sensory neurons, agonists for metabotropic glutamate re...

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Bibliografiska uppgifter
I publikationen:eNeuro
Huvudupphovsmän: Sheahan, Tayler D., Valtcheva, Manouela V., McIlvried, Lisa A., Pullen, Melanie Y., Baranger, David A.A., Gereau, Robert W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2018
Ämnen:
Negative Results
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898698/
https://ncbi.nlm.nih.gov/pubmed/29662945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0412-17.2018
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