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Group II mGluRs suppress hyperexcitability in mouse and human nociceptors

We introduce a strategy for preclinical research wherein promising targets for analgesia are tested in rodent and subsequently validated in human sensory neurons. Here, we evaluate group II metabotropic glutamate receptors, the activation of which is efficacious in rodent models of pain. Immunohisto...

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Publicat a:Pain
Autors principals: Davidson, Steve, Golden, Judith P., Copits, Bryan A., Ray, Pradipta R., Vogt, Sherri K., Valtcheva, Manouela V., Schmidt, Robert E., Ghetti, Andrea, Price, Theodore, Gereau, Robert W.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988887/
https://ncbi.nlm.nih.gov/pubmed/27218869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000621
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