Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation

INTRODUCTION: Colchicine is used for the treatment of gout, pseudo-gout, familial Mediterranean fever, and many other illnesses. Its oral administration is associated with poor bioavailability and severe gastrointestinal side effects. The drug is also known to have a low therapeutic index. Thus to o...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Abdulbaqi, Ibrahim M, Darwis, Yusrida, Assi, Reem Abou, Khan, Nurzalina Abdul Karim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2018
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898596/
https://ncbi.nlm.nih.gov/pubmed/29670336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S158018
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