Two Differential Binding Mechanisms of FG-Nucleoporins and Nuclear Transport Receptors

Phenylalanine-glycine-rich nucleoporins (FG-Nups) are intrinsically disordered proteins, constituting the selective barrier of the nuclear pore complex (NPC). Previous studies showed that nuclear transport receptors (NTRs) were found to interact with FG-Nups by forming an “archetypal-fuzzy” complex...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Tan, Piau Siong, Aramburu, Iker Valle, Mercadante, Davide, Tyagi, Swati, Chowdhury, Aritra, Spitz, Daniel, Shammas, Sarah L., Gräter, Frauke, Lemke, Edward A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898484/
https://ncbi.nlm.nih.gov/pubmed/29590630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.022
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