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Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging

Aging is the greatest risk factor for neurodegeneration, but the connection between the two processes remains opaque. This is in part for want of a rigorous way to define physiological age, as opposed to chronological age. Here, we develop a comprehensive metric for physiological age in Drosophila,...

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Bibliografske podrobnosti
izdano v:Dis Model Mech
Main Authors: Spurrier, Joshua, Shukla, Arvind Kumar, McLinden, Kristina, Johnson, Kory, Giniger, Edward
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897722/
https://ncbi.nlm.nih.gov/pubmed/29469033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.031161
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