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Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila

Altered function of Cdk5 kinase is associated with many forms of neurodegenerative disease in humans. We show here that inactivating the Drosophila Cdk5 ortholog, by mutation of its activating subunit, p35, causes adult-onset neurodegeneration in the fly. In the mutants, a vacuolar neuropathology is...

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Detaylı Bibliyografya
Asıl Yazarlar: Trunova, Svetlana, Giniger, Edward
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Limited 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291642/
https://ncbi.nlm.nih.gov/pubmed/22228754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.008847
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