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Connexin hemichannels mediate glutathione transport and protect lens fiber cells from oxidative stress

Elevated oxidized stress contributes to lens cataracts, and gap junctions play important roles in maintaining lens transparency. As well as forming gap junctions, connexin (Cx) proteins also form hemichannels. Here, we report a new mechanism whereby hemichannels mediate transport of reductant glutat...

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Bibliographic Details
Published in:J Cell Sci
Main Authors: Shi, Wen, Riquelme, Manuel A., Gu, Sumin, Jiang, Jean X.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897712/
https://ncbi.nlm.nih.gov/pubmed/29487175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.212506
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