Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model

Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies. We aimed to characterize the chemo-preventive effects of metformin, a widely used anti-diabetic dr...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Chang, Hui-Hua, Moro, Aune, Chou, Caroline Ei Ne, Dawson, David W., French, Samuel, Schmidt, Andrea I., Sinnett-Smith, James, Hao, Fang, Hines, O. Joe, Eibl, Guido, Rozengurt, Enrique
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897574/
https://ncbi.nlm.nih.gov/pubmed/29651002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24337-8
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