Metformin alters the duodenal microbiome and decreases the incidence of pancreatic ductal adenocarcinoma promoted by diet-induced obesity

Pancreatic ductal adenocarcinoma (PDAC)’s growing incidence has been linked to the rise in obesity and type 2 diabetes mellitus. In previous work, we have shown that metformin can prevent the increased incidence of PDAC in a Kras(G12D) mouse model subjected to a diet high in fat and calories (HFCD)....

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Bibliographic Details
Published in:Am J Physiol Gastrointest Liver Physiol
Main Authors: Dong, Tien S., Chang, Hui-Hua, Hauer, Meg, Lagishetty, Venu, Katzka, William, Rozengurt, Enrique, Jacobs, Jonathan P., Eibl, Guido
Format: Artigo
Language:Inglês
Published: American Physiological Society 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962494/
https://ncbi.nlm.nih.gov/pubmed/31545922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00170.2019
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