Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

Acute allergic symptoms are caused by allergen-induced crosslinking of allergen-specific immunoglobulin E (IgE) bound to Fc-epsilon receptors on effector cells. Desensitization with allergen-specific immunotherapy (SIT) has been used for over a century, but the dominant protective mechanism remains...

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Udgivet i:Nat Commun
Main Authors: Orengo, J. M., Radin, A. R., Kamat, V., Badithe, A., Ben, L. H., Bennett, B. L., Zhong, S., Birchard, D., Limnander, A., Rafique, A., Bautista, J., Kostic, A., Newell, D., Duan, X., Franklin, M. C., Olson, W., Huang, T., Gandhi, N. A., Lipsich, L., Stahl, N., Papadopoulos, N. J., Murphy, A. J., Yancopoulos, G. D.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897525/
https://ncbi.nlm.nih.gov/pubmed/29650949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03636-8
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