Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequence...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Hirose, Misa, Schilf, Paul, Gupta, Yask, Zarse, Kim, Künstner, Axel, Fähnrich, Anke, Busch, Hauke, Yin, Junping, Wright, Marvin N., Ziegler, Andreas, Vallier, Marie, Belheouane, Meriem, Baines, John F, Tautz, Diethard, Johann, Kornelia, Oelkrug, Rebecca, Mittag, Jens, Lehnert, Hendrik, Othman, Alaa, Jöhren, Olaf, Schwaninger, Markus, Prehn, Cornelia, Adamski, Jerzy, Shima, Kensuke, Rupp, Jan, Häsler, Robert, Fuellen, Georg, Köhling, Rüdiger, Ristow, Michael, Ibrahim, Saleh M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897405/
https://ncbi.nlm.nih.gov/pubmed/29651131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24290-6
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