Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequence...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hirose, Misa, Schilf, Paul, Gupta, Yask, Zarse, Kim, Künstner, Axel, Fähnrich, Anke, Busch, Hauke, Yin, Junping, Wright, Marvin N., Ziegler, Andreas, Vallier, Marie, Belheouane, Meriem, Baines, John F, Tautz, Diethard, Johann, Kornelia, Oelkrug, Rebecca, Mittag, Jens, Lehnert, Hendrik, Othman, Alaa, Jöhren, Olaf, Schwaninger, Markus, Prehn, Cornelia, Adamski, Jerzy, Shima, Kensuke, Rupp, Jan, Häsler, Robert, Fuellen, Georg, Köhling, Rüdiger, Ristow, Michael, Ibrahim, Saleh M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897405/
https://ncbi.nlm.nih.gov/pubmed/29651131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24290-6
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