AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus

Congenital nephrogenic diabetes insipidus (NDI) is characterized by the inability of the kidney to concentrate urine. Congenital NDI is mainly caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R), leading to impaired aquaporin-2 (AQP2) water channel activity. So far, treatme...

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Vydáno v:Nat Commun
Hlavní autoři: Ando, Fumiaki, Mori, Shuichi, Yui, Naofumi, Morimoto, Tetsuji, Nomura, Naohiro, Sohara, Eisei, Rai, Tatemitsu, Sasaki, Sei, Kondo, Yoshiaki, Kagechika, Hiroyuki, Uchida, Shinichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897355/
https://ncbi.nlm.nih.gov/pubmed/29650969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03771-2
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