Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

Clathrin-independent endocytosis (CIE) mediates internalization of many transmembrane proteins but the mechanisms of cargo recruitment during CIE are poorly understood. We found that the cell-permeable furopyrimidine AIM-100 promotes dramatic oligomerization, clustering and CIE of human and mouse do...

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Publicado en:eLife
Autores principales: Sorkina, Tatiana, Ma, Shiqi, Larsen, Mads Breum, Watkins, Simon C, Sorkin, Alexander
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896956/
https://ncbi.nlm.nih.gov/pubmed/29630493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32293
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