A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins

Despite their evolutionary, developmental, and functional importance the origin of vertebrate paired appendages remains uncertain. In mice, a single enhancer termed ZRS is solely responsible for Shh expression in limbs. Here, zebrafish and mouse transgenic assays trace the functional equivalence of...

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Bibliografiska uppgifter
I publikationen:Nat Genet
Huvudupphovsmän: Letelier, Joaquín, de la Calle-Mustienes, Elisa, Pieretti, Joyce, Naranjo, Silvia, Maeso, Ignacio, Nakamura, Tetsuya, Pascual-Anaya, Juan, Shubin, Neil, Schneider, Igor, Martinez-Morales, Juan Ramón, Gómez-Skarmeta, José Luis
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896732/
https://ncbi.nlm.nih.gov/pubmed/29556077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0080-5
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