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A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins
Despite their evolutionary, developmental, and functional importance the origin of vertebrate paired appendages remains uncertain. In mice, a single enhancer termed ZRS is solely responsible for Shh expression in limbs. Here, zebrafish and mouse transgenic assays trace the functional equivalence of...
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| Izdano u: | Nat Genet |
|---|---|
| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5896732/ https://ncbi.nlm.nih.gov/pubmed/29556077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0080-5 |
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