Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies

Anti-CD40 monoclonal antibodies (mAbs) that promote or inhibit receptor function hold promise as therapeutics for cancer and autoimmunity. Rules governing their diverse range of functions, however, are lacking. Here we determined characteristics of nine hCD40 mAbs engaging epitopes throughout the CD...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Yu, Xiaojie, Chan, H.T. Claude, Orr, Christian M., Dadas, Osman, Booth, Steven G., Dahal, Lekh N., Penfold, Christine A., O'Brien, Lyn, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick, Douglas, Leon R., Pearson, Arwen R., Cragg, Mark S., Tews, Ivo, Glennie, Martin J., White, Ann L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896247/
https://ncbi.nlm.nih.gov/pubmed/29576376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.02.009
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