Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

In Alzheimer’s disease, neurofibrillary tangle pathology appears to spread along neuronal connections, proposed to be mediated by the release and uptake of abnormal, disease-specific forms of microtubule-binding protein tau MAPT. It is currently unclear whether transfer of tau between neurons is a t...

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Vydáno v:Cell Rep
Hlavní autoři: Evans, Lewis D., Wassmer, Thomas, Fraser, Graham, Smith, James, Perkinton, Michael, Billinton, Andrew, Livesey, Frederick J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896171/
https://ncbi.nlm.nih.gov/pubmed/29590627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.021
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