Cas4 Facilitates PAM-Compatible Spacer Selection during CRISPR Adaptation

CRISPR-Cas systems adapt their immunological memory against their invaders by integrating short DNA fragments into clustered regularly interspaced short palindromic repeat (CRISPR) loci. While Cas1 and Cas2 make up the core machinery of the CRISPR integration process, various class I and II CRISPR-C...

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Udgivet i:Cell Rep
Main Authors: Kieper, Sebastian N., Almendros, Cristóbal, Behler, Juliane, McKenzie, Rebecca E., Nobrega, Franklin L., Haagsma, Anna C., Vink, Jochem N.A., Hess, Wolfgang R., Brouns, Stan J.J.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896167/
https://ncbi.nlm.nih.gov/pubmed/29590607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.103
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