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Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism

Duchenne muscular dystrophy (DMD) is the most common inherited muscle disorder that causes severe disability and death of young men. This disease is characterized by progressive muscle degeneration aggravated by sterile inflammation and is also associated with cognitive impairment and low bone densi...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Al-Khalidi, Rasha, Panicucci, Chiara, Cox, Paul, Chira, Natalia, Róg, Justyna, Young, Christopher N. J., McGeehan, Rhiannon E., Ambati, Kameshwari, Ambati, Jayakrishna, Zabłocki, Krzysztof, Gazzerro, Elisabetta, Arkle, Stephen, Bruno, Claudio, Górecki, Dariusz C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896059/
https://ncbi.nlm.nih.gov/pubmed/29642926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0530-4
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