Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through Fgf4/Fgfr2 signaling in preimplantation mouse embryos

Oct4 and Sox2 regulate the expression of target genes such as Nanog, Fgf4, and Utf1, by binding to their respective regulatory motifs. Their functional cooperation is reflected in their ability to heterodimerize on adjacent cis regulatory motifs, the composite Sox/Oct motif. Given that Oct4 and Sox2...

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Bibliographic Details
Published in:Biochem J
Main Authors: Mistri, Tapan Kumar, Arindrarto, Wibowo, Ng, Wei Ping, Wang, Choayang, Lim, Leng Hiong, Sun, Lili, Chambers, Ian, Wohland, Thorsten, Robson, Paul
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896025/
https://ncbi.nlm.nih.gov/pubmed/29487166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170418
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