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Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation

Activating mutations in fibroblast growth factor receptor 2 (FGFR2) cause several craniosynostosis syndromes by affecting the proliferation and differentiation of osteoblasts, which form the calvarial bones. Osteoblasts respond to FGF with increased proliferation and inhibition of differentiation. W...

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Detalhes bibliográficos
Main Authors: Mansukhani, Alka, Ambrosetti, Davide, Holmes, Greg, Cornivelli, Lizbeth, Basilico, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171836/
https://ncbi.nlm.nih.gov/pubmed/15781477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200409182
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