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The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic mice

We have previously shown that in osteoblasts Sox2 expression can be induced by Fgfs, and can inhibit Wnt signaling and differentiation. Furthermore, in mice in which Sox2 is conditionally deleted in the osteoblastic lineage, bones are osteopenic, and Sox2 inactivation in cultured osteoblasts leads t...

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Detalhes bibliográficos
Main Authors: Holmes, Greg, Bromage, Timothy G., Basilico, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167013/
https://ncbi.nlm.nih.gov/pubmed/21703370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2011.06.008
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