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Activation of the DnaK-ClpB Complex is Regulated by the Properties of the Bound Substrate

The chaperone ClpB in bacteria is responsible for the reactivation of aggregated proteins in collaboration with the DnaK system. Association of these chaperones at the aggregate surface stimulates ATP hydrolysis, which mediates substrate remodeling. However, a question that remains unanswered is whe...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Fernández-Higuero, Jose Angel, Aguado, Alejandra, Perales-Calvo, Judit, Moro, Fernando, Muga, Arturo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895705/
https://ncbi.nlm.nih.gov/pubmed/29643454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24140-5
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