Modulation of the Chaperone DnaK Allosterism by the Nucleotide Exchange Factor GrpE

Hsp70 chaperones comprise two domains, the nucleotide-binding domain (Hsp70(NBD)), responsible for structural and functional changes in the chaperone, and the substrate-binding domain (Hsp70(SBD)), involved in substrate interaction. Substrate binding and release in Hsp70 is controlled by the nucleot...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Melero, Roberto, Moro, Fernando, Pérez-Calvo, María Ángeles, Perales-Calvo, Judit, Quintana-Gallardo, Lucía, Llorca, Oscar, Muga, Arturo, Valpuesta, José María
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400324/
https://ncbi.nlm.nih.gov/pubmed/25739641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.623371
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