PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma

Rhabdomyosarcoma is the most common soft-tissue sarcoma in childhood and histologically resembles developing skeletal muscle. Alveolar rhabdomyosarcoma (ARMS) is an aggressive subtype with a higher rate of metastasis and poorer prognosis. The majority of ARMS tumors (80%) harbor a PAX3-FOXO1 or less...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Hanna, Jason A., Garcia, Matthew R., Lardennois, Alicia, Leavey, Patrick J., Maglic, Dino, Fagnan, Alexandre, Go, Jonathan C., Roach, Jordan, Wang, Yong-Dong, Finkelstein, David, Hatley, Mark E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895609/
https://ncbi.nlm.nih.gov/pubmed/29367756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0081-3
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