The HDAC3-SMARCA4-miR27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with an unmet clinical need for decades. A single oncogenic fusion gene is associated with treatment resistance and a 40 to 45% decrease in overall survival. We previously showed that expression of this PAX3:FOXO1 fusion onco...

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Bibliografiset tiedot
Julkaisussa:Sci Signal
Päätekijät: Bharathy, Narendra, Berlow, Noah E., Wang, Eric, Abraham, Jinu, Settelmeyer, Teagan P., Hooper, Jody E., Svalina, Matthew N., Ishikawa, Yoshihiro, Zientek, Keith, Bajwa, Zia, Goros, Martin W., Hernandez, Brian S., Wolff, Johannes E., Rudek, Michelle A., Xu, Linping, Anders, Nicole M., Pal, Ranadip, Harrold, Alexandria P., Davies, Angela M., Ashok, Arya, Bushby, Darnell, Mancini, Maria, Noakes, Christopher, Goodwin, Neal C., Ordentlich, Peter, Keck, James, Hawkins, Douglas S., Rudzinski, Erin R., Chatterjee, Bishwanath, Bächinger, Hans Peter, Barr, Frederic G., Liddle, Jennifer, Garcia, Benjamin A., Mansoor, Atiya, Perkins, Theodore J., Vakoc, Christopher R., Michalek, Joel E., Keller, Charles
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432638/
https://ncbi.nlm.nih.gov/pubmed/30459282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau7632
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