The HDAC3-SMARCA4-miR27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with an unmet clinical need for decades. A single oncogenic fusion gene is associated with treatment resistance and a 40 to 45% decrease in overall survival. We previously showed that expression of this PAX3:FOXO1 fusion onco...

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Pubblicato in:Sci Signal
Autori principali: Bharathy, Narendra, Berlow, Noah E., Wang, Eric, Abraham, Jinu, Settelmeyer, Teagan P., Hooper, Jody E., Svalina, Matthew N., Ishikawa, Yoshihiro, Zientek, Keith, Bajwa, Zia, Goros, Martin W., Hernandez, Brian S., Wolff, Johannes E., Rudek, Michelle A., Xu, Linping, Anders, Nicole M., Pal, Ranadip, Harrold, Alexandria P., Davies, Angela M., Ashok, Arya, Bushby, Darnell, Mancini, Maria, Noakes, Christopher, Goodwin, Neal C., Ordentlich, Peter, Keck, James, Hawkins, Douglas S., Rudzinski, Erin R., Chatterjee, Bishwanath, Bächinger, Hans Peter, Barr, Frederic G., Liddle, Jennifer, Garcia, Benjamin A., Mansoor, Atiya, Perkins, Theodore J., Vakoc, Christopher R., Michalek, Joel E., Keller, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432638/
https://ncbi.nlm.nih.gov/pubmed/30459282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau7632
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