The HDAC3-SMARCA4-miR27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with an unmet clinical need for decades. A single oncogenic fusion gene is associated with treatment resistance and a 40 to 45% decrease in overall survival. We previously showed that expression of this PAX3:FOXO1 fusion onco...

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Udgivet i:Sci Signal
Main Authors: Bharathy, Narendra, Berlow, Noah E., Wang, Eric, Abraham, Jinu, Settelmeyer, Teagan P., Hooper, Jody E., Svalina, Matthew N., Ishikawa, Yoshihiro, Zientek, Keith, Bajwa, Zia, Goros, Martin W., Hernandez, Brian S., Wolff, Johannes E., Rudek, Michelle A., Xu, Linping, Anders, Nicole M., Pal, Ranadip, Harrold, Alexandria P., Davies, Angela M., Ashok, Arya, Bushby, Darnell, Mancini, Maria, Noakes, Christopher, Goodwin, Neal C., Ordentlich, Peter, Keck, James, Hawkins, Douglas S., Rudzinski, Erin R., Chatterjee, Bishwanath, Bächinger, Hans Peter, Barr, Frederic G., Liddle, Jennifer, Garcia, Benjamin A., Mansoor, Atiya, Perkins, Theodore J., Vakoc, Christopher R., Michalek, Joel E., Keller, Charles
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432638/
https://ncbi.nlm.nih.gov/pubmed/30459282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau7632
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