Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

Altered re-wiring of cell metabolism and transcriptional programs are both hallmarks of cancer that sustain rapid proliferation and metastasis(1). However mechanisms controlling the interplay between metabolic reprogramming and transcriptional regulation remain elusive. Here we show that metabolic e...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Dasgupta, Subhamoy, Rajapakshe, Kimal, Zhu, Bokai, Nikolai, Bryan C., Yi, Ping, Putluri, Nagireddy, Choi, Jong Min, Jung, Sung Y., Coarfa, Cristian, Westbrook, Thomas F., Zhang, Xiang H.-F., Foulds, Charles E., Tsai, Sophia Y., Tsai, Ming-Jer, O’Malley, Bert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895503/
https://ncbi.nlm.nih.gov/pubmed/29615789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0018-1
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