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HEx: A heterologous expression platform for the discovery of fungal natural products

For decades, fungi have been a source of U.S. Food and Drug Administration–approved natural products such as penicillin, cyclosporine, and the statins. Recent breakthroughs in DNA sequencing suggest that millions of fungal species exist on Earth, with each genome encoding pathways capable of generat...

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Publié dans:Sci Adv
Auteurs principaux: Harvey, Colin J. B., Tang, Mancheng, Schlecht, Ulrich, Horecka, Joe, Fischer, Curt R., Lin, Hsiao-Ching, Li, Jian, Naughton, Brian, Cherry, James, Miranda, Molly, Li, Yong Fuga, Chu, Angela M., Hennessy, James R., Vandova, Gergana A., Inglis, Diane, Aiyar, Raeka S., Steinmetz, Lars M., Davis, Ronald W., Medema, Marnix H., Sattely, Elizabeth, Khosla, Chaitan, St. Onge, Robert P., Tang, Yi, Hillenmeyer, Maureen E.
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895447/
https://ncbi.nlm.nih.gov/pubmed/29651464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aar5459
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