Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C

Protein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular functions, making them extensively studied and highly attractive drug targets. Utilizing the crystal structure of the PKCδ C1B domain, we have developed hydrophobic isophthalic acid derivatives that modify PKC...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Provenzani, Riccardo, Tarvainen, Ilari, Brandoli, Giulia, Lempinen, Antti, Artes, Sanna, Turku, Ainoleena, Jäntti, Maria Helena, Talman, Virpi, Yli-Kauhaluoma, Jari, Tuominen, Raimo K., Boije af Gennäs, Gustav
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895059/
https://ncbi.nlm.nih.gov/pubmed/29641588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195668
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker