Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C

Protein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular functions, making them extensively studied and highly attractive drug targets. Utilizing the crystal structure of the PKCδ C1B domain, we have developed hydrophobic isophthalic acid derivatives that modify PKC...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Provenzani, Riccardo, Tarvainen, Ilari, Brandoli, Giulia, Lempinen, Antti, Artes, Sanna, Turku, Ainoleena, Jäntti, Maria Helena, Talman, Virpi, Yli-Kauhaluoma, Jari, Tuominen, Raimo K., Boije af Gennäs, Gustav
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895059/
https://ncbi.nlm.nih.gov/pubmed/29641588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195668
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados