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Alternative inflammasome activation enables IL-1β release from living cells
Classical modes of NLRP3 activation entail a priming step that enables its activation (signal 1) and a potassium efflux-dependent activation signal (signal 2) that triggers pyroptosome formation and pyroptosis, a lytic cell death necessary for IL-1β release. Opposing to that, human monocytes engage...
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| Udgivet i: | Curr Opin Immunol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5894802/ https://ncbi.nlm.nih.gov/pubmed/27842238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2016.10.007 |
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