The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis

Pulmonary fibrosis is thought to result from dysregulated wound repair after repetitive lung injury. Many cellular responses to injury involve rearrangements of the actin cytoskeleton mediated by the two isoforms of the Rho-associated coiled-coil–forming protein kinase (ROCK), ROCK1 and ROCK2. In ad...

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Veröffentlicht in:Am J Respir Cell Mol Biol
Hauptverfasser: Knipe, Rachel S., Probst, Clemens K., Lagares, David, Franklin, Alicia, Spinney, Jillian J., Brazee, Patricia L., Grasberger, Paula, Zhang, Linlin, Black, Katharine E., Sakai, Norihiko, Shea, Barry S., Liao, James K., Medoff, Benjamin D., Tager, Andrew M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2018
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894496/
https://ncbi.nlm.nih.gov/pubmed/29211497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0075OC
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