Distinct and Complementary Functions of Rho kinase isoforms ROCK1 and ROCK2 in Prefrontal Cortex Structural Plasticity

Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approa...

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Detalhes bibliográficos
Publicado no:Brain Struct Funct
Main Authors: Greathouse, Kelsey M., Boros, Benjamin D., Deslauriers, Josue F., Henderson, Benjamin W., Curtis, Kendall A., Gentry, Erik G., Herskowitz, Jeremy H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6252131/
https://ncbi.nlm.nih.gov/pubmed/30196430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00429-018-1748-4
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