Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance

The use of genome-wide copy-number analysis and massive parallel sequencing has revolutionized the understanding of the clonal architecture of pediatric acute lymphoblastic leukemia (ALL) by demonstrating that this disease is composed of highly variable clonal ancestries following the rules of Darwi...

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Publicado en:Exp Hematol
Main Authors: Nowak, Daniel, Liem, Natalia L.M., Mossner, Maximilian, Klaumünzer, Marion, Papa, Rachael A., Nowak, Verena, Jann, Johann C., Akagi, Tadayuki, Kawamata, Norihiko, Okamoto, Ryoko, Thoennissen, Nils H., Kato, Motohiro, Sanada, Masashi, Hofmann, Wolf-Karsten, Ogawa, Seishi, Marshall, Glenn M., Lock, Richard B., Koeffler, H. Phillip
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894481/
https://ncbi.nlm.nih.gov/pubmed/25450514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2014.09.007
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