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Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP(5+), and its alkoxyalkyl analogues
We disclose here the studies that preceded and guided the preparation of the metal-based, redox-active therapeutic Mn(III) meso-tetrakis(N-n-butoxyethylpyridyl)porphyrin, MnTnBuOE-2-PyP(5+) (BMX-001), which is currently in Phase I/II Clinical Trials at Duke University as a radioprotector of normal t...
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| Udgivet i: | J Inorg Biochem |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5893775/ https://ncbi.nlm.nih.gov/pubmed/28131001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2017.01.003 |
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