Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP(5+), and its alkoxyalkyl analogues

We disclose here the studies that preceded and guided the preparation of the metal-based, redox-active therapeutic Mn(III) meso-tetrakis(N-n-butoxyethylpyridyl)porphyrin, MnTnBuOE-2-PyP(5+) (BMX-001), which is currently in Phase I/II Clinical Trials at Duke University as a radioprotector of normal t...

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Gepubliceerd in:J Inorg Biochem
Hoofdauteurs: Rajic, Zrinka, Tovmasyan, Artak, de Santana, Otávio L., Peixoto, Isabelle N., Spasojevic, Ivan, do Monte, Silmar A., Ventura, Elizete, Rebouças, Júlio S., Batinic-Haberle, Ines
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893775/
https://ncbi.nlm.nih.gov/pubmed/28131001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2017.01.003
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