In cancer cell lines inhibition of SCF/c-Kit pathway leads to radiosensitization only when SCF is strongly over-expressed

BACKGROUND AND PURPOSE: The SCF/c-Kit pathway is often overexpressed in human tumors leading to an enhanced tumorigenesis, proliferation and migration. It was now tested for NSCLC and prostate cancer cells growing in 2D and 3D whether the inhibition of this pathway can be used to achieve a significa...

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Vydáno v:Clin Transl Radiat Oncol
Hlavní autoři: Eberle, Fabian, Leinberger, Florian H., Saulich, Miriam F., Seeger, Werner, Engenhart-Cabillic, Rita, Hänze, Jörg, Hattar, Katja, Dikomey, Ekkehard, Subtil, Florentine S.B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893519/
https://ncbi.nlm.nih.gov/pubmed/29658004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ctro.2017.02.001
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