Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

PURPOSE: Naturally occurring tumor suppressor microRNA-34a (miR-34a) downregulates the expression of >30 oncogenes across multiple oncogenic pathways, as well as genes involved in tumor immune evasion, but is lost or under-expressed in many malignancies. This first-inhuman, phase I study assessed...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Invest New Drugs
Main Authors: Beg, Muhammad S., Brenner, Andrew J., Sachdev, Jasgit, Borad, Mitesh, Kang, Yoon-Koo, Stoudemire, Jay, Smith, Susan, Bader, Andreas G., Kim, Sinil, Hong, David S.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893501/
https://ncbi.nlm.nih.gov/pubmed/27917453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-016-0407-y
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