Contribution of Adipose-derived Factor D/Adipsin to Alternative Pathway Complement Activation: Lessons from Lipodystrophy

Factor D (FD) is an essential component of the complement alternative pathway (AP). It is an attractive pharmaceutical target because it is an AP-specific protease circulating in blood. Most components of the complement activation pathways are produced by the liver, but FD is highly expressed by adi...

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Pubblicato in:J Immunol
Autori principali: Wu, Xiaobo, Hutson, Irina, Akk, Antonina M., Mascharak, Smita, Pham, Christine T.N., Hourcade, Dennis E., Brown, Rebecca, Atkinson, John P., Harris, Charles A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893424/
https://ncbi.nlm.nih.gov/pubmed/29531168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701668
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