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B cell-intrinsic mTORC1 promotes GC-defining transcription factor gene expression, somatic hypermutation, and memory B cell generation in humoral immunity

B lymphocytes migrate among varied micro-environmental niches during diversification, selection, and conversion to memory or antibody-secreting plasma cells. Aspects of the nutrient milieu differ within these lymphoid micro-environments and can influence signaling molecules such as the mechanistic T...

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Bibliografiska uppgifter
I publikationen:	J Immunol
Huvudupphovsmän:	Raybuck, Ariel L., Cho, Sung Hoon, Li, Jingxin, Rogers, Meredith C., Lee, Keunwook, Williams, Christopher L., Shlomchik, Mark, Thomas, James W., Chen, Jin, Williams, John V., Boothby, Mark R.
Materialtyp:	Artigo
Språk:	Inglês
Publicerad:	2018
Ämnen:	Article
Länkar:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5893413/ https://ncbi.nlm.nih.gov/pubmed/29531165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701321
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B cell-intrinsic mTORC1 promotes GC-defining transcription factor gene expression, somatic hypermutation, and memory B cell generation in humoral immunity

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