EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration

Microtubules have long been implicated to play an integral role in metastatic disease, for which a critical step is the local invasion of tumor cells into the 3-dimensional (3D) collagen-rich stromal matrix. Here we show that cell migration of human cancer cells uses the dynamic formation of highly...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Jayatilaka, Hasini, Giri, Anjil, Karl, Michelle, Aifuwa, Ivie, Trenton, Nicholaus J., Phillip, Jude M., Khatau, Shyam, Wirtz, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893312/
https://ncbi.nlm.nih.gov/pubmed/29097501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700444RR
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