Inhibitors of LexA autoproteolysis and the bacterial SOS response discovered by an academic-industry partnership

The RecA/LexA axis of the bacterial DNA damage (SOS) response is a promising, yet non-traditional drug target. The SOS response is initiated upon genotoxic stress, when RecA, a DNA damage sensor, induces LexA, the SOS repressor, to undergo autoproteolysis, thereby de-repressing downstream genes that...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ACS Infect Dis
Egile Nagusiak: Mo, Charlie Y., Culyba, Matthew J., Selwood, Trevor, Kubiak, Jeffrey M., Hostetler, Zachary M., Jurewicz, Anthony J., Keller, Paul M., Pope, Andrew J., Quinn, Amy, Schneck, Jessica, Widdowson, Katherine L., Kohli, Rahul M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893282/
https://ncbi.nlm.nih.gov/pubmed/29275629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00122
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