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Inhibitors of LexA autoproteolysis and the bacterial SOS response discovered by an academic-industry partnership
The RecA/LexA axis of the bacterial DNA damage (SOS) response is a promising, yet non-traditional drug target. The SOS response is initiated upon genotoxic stress, when RecA, a DNA damage sensor, induces LexA, the SOS repressor, to undergo autoproteolysis, thereby de-repressing downstream genes that...
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| Publicado no: | ACS Infect Dis |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5893282/ https://ncbi.nlm.nih.gov/pubmed/29275629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00122 |
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