Inhibitors of LexA autoproteolysis and the bacterial SOS response discovered by an academic-industry partnership

The RecA/LexA axis of the bacterial DNA damage (SOS) response is a promising, yet non-traditional drug target. The SOS response is initiated upon genotoxic stress, when RecA, a DNA damage sensor, induces LexA, the SOS repressor, to undergo autoproteolysis, thereby de-repressing downstream genes that...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ACS Infect Dis
Autores principales: Mo, Charlie Y., Culyba, Matthew J., Selwood, Trevor, Kubiak, Jeffrey M., Hostetler, Zachary M., Jurewicz, Anthony J., Keller, Paul M., Pope, Andrew J., Quinn, Amy, Schneck, Jessica, Widdowson, Katherine L., Kohli, Rahul M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893282/
https://ncbi.nlm.nih.gov/pubmed/29275629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00122
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares