Switching Cyclic Nucleotide-Selective Activation of Cyclic Adenosine Monophosphate-Dependent Protein Kinase Holoenzyme Reveals Distinct Roles of Tandem Cyclic Nucleotide-Binding Domains

The cyclic adenosine monophosphate (cAMP)- and cyclic guanosine monophosphate (cGMP)-dependent protein kinases (PKA and PKG) are key effectors of cyclic nucleotide signaling. Both share structural features that include tandem cyclic nucleotide-binding (CNB) domains, CNB-A and CNB-B, yet their functi...

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Publicado en:ACS Chem Biol
Main Authors: He, Daniel, Lorenz, Robin, Kim, Choel, Herberg, Friedrich W., Lim, Chinten James
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892833/
https://ncbi.nlm.nih.gov/pubmed/29111666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00732
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