Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes

Accumulating data support a role for bioactive lipids as mediators of lipotixicity in cardiomyocytes. One class of these, the ceramides, constitutes a family of molecules that differ in structure and are synthesized by distinct enzymes, ceramide synthase (CerS)1–CerS6. Data support that specific cer...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Law, Brittany A., Liao, Xianghai, Moore, Kelsey S., Southard, Abigail, Roddy, Patrick, Ji, Ruiping, Szulc, Zdzislaw, Bielawska, Ala, Schulze, P. Christian, Cowart, L. Ashley
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892719/
https://ncbi.nlm.nih.gov/pubmed/29127192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700300R
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